I am having significant trouble installing psycopg2 in OSX. After installing Postgresql 9.5.4_1 using homebrew I attempted to install psycopg2 in my virtual environment:
pip install psycopg2
ld: library not found for -lssl
clang: error: linker command failed with exit code 1 (use -v to see invocation)
error: command 'clang' failed with exit status 1
Failed building wheel for psycopg2
Command "/Users/*username*/.virtualenvs/report/bin/python3.5 -u -c "import setuptools, tokenize;__file__='/private/var/folders/9p/3_wdgjzd03d6bw1p_c9rrt6c0000gp/T/pip-build-cuplxne2/psycopg2/setup.py';exec(compile(getattr(tokenize, 'open', open)(__file__).read().replace('\r\n', '\n'), __file__, 'exec'))" install --record /var/folders/9p/3_wdgjzd03d6bw1p_c9rrt6c0000gp/T/pip-8gbk007q-record/install-record.txt --single-version-externally-managed --compile --install-headers /Users/*username*/.virtualenvs/report/bin/../include/site/python3.5/psycopg2" failed with error code 1 in /private/var/folders/9p/3_wdgjzd03d6bw1p_c9rrt6c0000gp/T/pip-build-cuplxne2/psycopg2/
This seems to be an issue with Homebrew's update of for OSX sierra. I was able to finally fix this issue by uninstalling and reinstalling python 3.5 and postgresql with homebrew and then trying to install psycopg2 again.