DigiHard - 4 months ago 33

R Question

I use igraph package to get motifs in Protein-Protein interaction network, It has a vector output, But I need plot or draw of motifs, figure of motifs.

code in R:

`motifs(graph_object, size = 3)`

output:

1 NA NA 5 3

How to I get plot of motifs in R and igraph? Here have we four motifs?

Note: This question is different from How to mine for motifs in R with iGraph

Answer

Construct the motif that you want to search for as a "template graph" (for instance, create a triangle graph), then use `subgraph_isomorphisms`

to find all the mappings from the vertices of the template graph from the vertices of your protein-protein interaction network, and `induced_subgraph`

combined with `lapply`

to transform the list of mappings into the actual motifs. Example:

```
> pattern <- graph.full(3)
> my.graph <- grg.game(100, 0.2) # just an example graph, use yours
> iso <- subgraph_isomorphisms(pattern, my.graph) # takes a while
> motifs <- lapply(iso, function (x) { induced_subgraph(my.graph, x) })
```

`motifs`

will then be a list of graphs, and you can plot them one by one using `plot()`

.