I referenced Missing Typescript Options in Web Essential for Visual Studio 2012
It says Split panes have been reintroduced in the latest version of web essentials http://vswebessentials.com/features/typescript but I can not see it
I do have typescript exe in following folder
C:\Program Files (x86)\Microsoft SDKs\TypeScript\1.5
I regularly encounter this issue in VS 2015 and VS 2013. My solution is not a pretty one, but it works for me...
If this doesn't work, open each TypeScript file, change one character, Save, re-build... hopefully the file will re-compile.
If this still doesn't work, open a Node.JS command prompt, change directory to the scripts directory, run;
If this doesn't work, you've got bigger problems.