user24318 - 7 months ago 28

R Question

I am working on simulating a longitudinal data set with irregular visit structure.

I want to add a column of "participants age at visit" starting from baseline visit.

(say baseline age is 65 and suppose the time intervals are (1,1.2,2,2.5) then I want to generate a new variable called "age.at.visit" which will have age (65,66,67.2,69.2,71.7).

Basically, adding intervals cumulatively to baseline age of 65 i.e. (65+1,65+1+1.2, 65+1.1.2+2, 65+1+1.2+2+2.5). I have simulated age at baseline and I want to add time interval to the baseline age based on the number of visits the participant had. I am struggling to generate the cumulative sum and need help. Here is my attempt

`maxvst = 10; # maximum number of visits`

nsubj = 100; #number of participants or subjects

nvstsubj = sample(1:maxvst,nsubj,replace=TRUE) # generate visit for each subj

bage=runif(nsubj,65,100) #baseline age

subj=rep(1:nsubj, nvstsubj) # subject ids

#generate visits and age of participants

visit=rep(0,length(subject))

age =rep(0,length(subject))

for (i in 1:nsubj){

idx = subject==i

vi = nvstsubj[i]

visit[idx] = 1:vi

intervals = runif(vi-1,1,3) #generate time intervals to add to baseline age

# generate age at each visits

age[idx]= # ??? cumulative sum over interval

}

Answer

This type of thing is often best kept in a list. I recreated your data to keep it all in a single data frame.

```
df <- data.frame(id = 1:100,
num_visits=sample(1:10,100,replace=TRUE),
base_age = runif(100, 65, 100))
```

Data looks like this

```
head(df,4)
id num_visits base_age
1 1 2 67.90497
2 2 3 70.77535
3 3 6 97.05501
4 4 6 77.31996
```

Then I applied the cumsum function to the duration between subsequent visits and added this to each row's base age. Note that, if there is only more than 1 visit you need to concatenate base age.

```
a <- apply(df,1, function(x) {
temp <- as.numeric(x["base_age"] + cumsum(runif(x["num_visits"], 1,2)))
if(length(temp) > 0) temp <- c(x["base_age"], temp)
})
```

Solution looks like this

```
[[1]]
base_age
67.90497 69.85027 71.30138
[[2]]
base_age
70.77535 72.34506 73.88659 75.21282
[[3]]
base_age
97.05501 98.57490 100.01887 101.50815 102.52040 104.36888 105.62224
[[4]]
base_age
77.31996 78.65842 80.17729 82.10347 83.60191 85.11311 86.18387
```