It seems that wireless ADB has more and more issues each time I update Android Studio. Using 2.1.1, I'm now unable to connect to my tablet using the command:
adb connect <ip addr>
unable to connect to <ip addr>:5555: cannot connect to <ip addr>:5555: No connection could be made because the target machine actively refused it. (10061)
Recently i face this problem. Because your device and PC connected different Network.